首页 体育 教育 财经 社会 娱乐 军事 国内 科技 互联网 房产 国际 女人 汽车 游戏

12月20日化工学院

2020-01-20

讲座标题:Magnesium Metals with Polymer Composite Coatings for Orthopedic Applications

聚合物基复合涂层包裹的镁金属及其在骨修正范畴的使用

主讲嘉宾:魏涛 教授

讲座时刻: 2019年12月20日 10:00-11:30

讲座地址: 化工楼A316

陈述摘要:Magnesium and its alloys have been intensively explored as the next-generation of metallic bone substitutes in the past decades, but their rapid corrosion rate in physiological environments is still a great hindrance for further therapeutic applications. In this talk, I will introduce our recent work in designing the biodegradable poly coatings on pure Mg substrates with tunable surface morphologies through dip-coating in combination with mixed non-solvent induced phase separation method to regulate the corrosion behavior and biocompatibility. By using the mixtures of solvents, we obtained PLLA coatings with different pore sizes and morphologies. We further developed an organic-inorganic composite coating consisting of PLLA and water-soluble Mg salt particles served as a protective layer on the surface of a pure Mg substrate. Compared to the pure PLLA coating, the implementation of the Mg salt coating could allow for quick initial release of Mg2+and impeded degradation of the Mg substrate simultaneously. In particular, we demonstrated that the composite-coated sample favored cellular adhesion and attachment, cell spreading, and cellular proliferation. These encouragingin vitrodata provide significant evidence of the potential practical value of this PLLA-based composite coating on Mg substrates for numerous orthopedic applications.

陈述简介:镁及镁合金是下一代骨修正及代替资料的研讨热门,可是其在体液环境下的快速降解阻止了其在临床的进一步使用。在该陈述中,陈述人将体系介绍经过浸涂办法制备的外表描摹可控的生物可降解聚乳酸涂层。将该涂层涂覆于纯度大于99.99%的金属镁外表,经过非溶剂调理分相程度和分相速度,得到具有不同孔径和描摹的聚合物涂层,这能够调控腐蚀速率和生物相容性。进一步地,咱们制备了聚乳酸和镁盐构成的有机-无机复合涂层。镁盐颗粒能够作为纯镁基底的保护膜,这一方面能够供给开释初期的镁离子,另一方面能够下降镁基底的腐蚀速率。复合涂层供给了更好的细胞黏附、细胞铺展和细胞增殖。因而,这些体外数据为聚乳酸基的聚合物复合涂层在镁基骨修正范畴的实践使用供给了重要的根底。

陈述人简介:魏涛,博士,香港中文大学化学系教授,理学院助理院长,英国皇家化学学会会士。他在香港中文大学师从吴奇院士,研讨高分子激光光散射和高分子溶液理论,于2003年取得博士学位;随后赴德国巴斯夫路德维希总部展开了两年的博士后作业,首要研讨范畴为胶体与外表化学。之后赴明尼苏达大学Timothy P. Lodge课题组展开了短期研讨。他于2006年在香港中文大学任职,于2017年升任正教授。他现在的研讨范畴首要为胶体、外表化学、高分子和软物质等。

热门文章

随机推荐

推荐文章